Immunohistochemistry of paraffin-embedded Human colon cancer tissue using PIK3R3 Polyclonal Antibody at dilution 1:45
Immunohistochemistry of paraffin-embedded Human colon cancer tissue using PIK3R3 Polyclonal Antibody at dilution 1:45
PIK3R3 Polyclonal Antibody
E-AB-13018
Product group Antibodies
Overview
- SupplierElabscience
- Product NamePIK3R3 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration0.4mg/ml
- Scientific DescriptionPhosphatidylinositol 3-kinase is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol and related compounds at the 3 position. PI 3-kinase p55 (PIK3R3) is comprised of a catalytic subunit and a regulatory subunit. The human p55 protein is composed of a rare amino terminal region followed by a proline-rich motif and two Src homology 2 (SH2) domains. PI 3-kinase p55 mRNAs are expressed in most human fetal and adult tissues; predominant expression is observed in the adult testis. Splice variant(s) of PI 3-kinase p55 have been identified; one of which has a deletion of 36 amino acids at the amino terminus and another which has an insertion of 59 amino acids at position 256 between the SH2 domains. Research suggests that PI 3-kinase p55 interacts with the IGFIR (Insulin-like growth factor-I receptor) and IR (Insulin receptor) and may be involved in PI 3-kinase activation by these receptors.
- UNSPSC12352203