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ProductsBack/Piperlongumine [20069-09-4]

Piperlongumine [20069-09-4]

Research Use Only
P3561
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 293,00
100 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Piperlongumine [20069-09-4]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    DMSO (~25 mg/ml)
  • Scientific Description
    Found in Piper longum; TxA2 antagonist, ubiquitin-proteasome inhibitor.; 1-[(2E)-3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2-(1H)-one, Piplartine
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Ginzburg S, Golovine KV, Makhov PB, et al. Piperlongumine inhibits NF-kappaB activity and attenuates aggressive growth characteristics of prostate cancer cells. Prostate. 2013 Oct 22. [Epub ahead of print]. PMID: 24151226. Wang Y, Wang JW, Xiao X, et al. Piperlongumine induces autophagy by targeting p38 signaling. Cell Death Dis. 2013 Oct 3;4:e824. PMID: 24091667. Liu JM, Pan F, Li L, et al. Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation. Biochem Biophys Res Commun. 2013 Jul 19;437(1):87-93. PMID: 23796709. Jarvius M, Fryknäs M, D'Arcy P, et al. Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells. Biochem Biophys Res Commun. 2013 Feb 8;431(2):117-23. PMID: 23318177. Son DJ, Kim SY, Han SS, et al. Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. Biochem Biophys Res Commun. 2012 Oct 19;427(2):349-54. PMID: 22995306. Golovine KV, Makhov PB, Teper E, et al. Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. Prostate. 2013 Jan;73(1):23-30. PMID: 22592999. Iwashita M, Oka N, Ohkubo S, et al. Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist. Eur J Pharmacol. 2007 Sep 10;570(1-3):38-42. PMID: 17618620. Niu M, Xu X, Shen Y, Yao Y et al., Piperlongumine is a novel nuclear export inhibitor with potent anticancer activity. Chem Biol Interact. 2015 Jul 25;237:66-72. PMID: 26026911 DOI: 10.1016/j.cbi.2015.05.016.