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ProductsBack/Pixantrone Dimaleate [144675-97-8]

Pixantrone Dimaleate [144675-97-8]

Research Use Only
P3592
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 967,00
100 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Pixantrone Dimaleate [144675-97-8]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Scientific Description
    Aza-anthracenedione, DNA intercalator; topoisomerase II inhibitor.; 5,8-bis(2-aminoethylamino)-1-azaanthracene-9,10-dione, BBR2778
  • Storage Instruction
    Ambient
  • UNSPSC
    12352200

References

  • Péan E, Flores B, Hudson I, et al. The European Medicines Agency review of pixantrone for the treatment of adult patients with multiply relapsed or refractory aggressive non-Hodgkin's B-cell lymphomas: summary of the scientific assessment of the committee for medicinal products for human use. Oncologist. 2013;18(5):625-33. PMID: 23615696. Marolda R, Ruocco C, Cordiglieri C, et al. Differential targeting of immune-cells by Pixantrone in experimental myasthenia gravis. J Neuroimmunol. 2013 May 15;258(1-2):41-50. PMID: 23523328. Adnan N, Buck DP, Evison BJ, et al. DNA binding by pixantrone. Org Biomol Chem. 2010 Dec 7;8(23):5359-66. PMID: 20865205. Colombo R, Carotti A, Catto M, et al. CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity. Electrophoresis. 2009 Apr;30(8):1418-29. PMID: 19306269. Evison BJ, Chiu F, Pezzoni G, et al. Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets. Mol Pharmacol. 2008 Jul;74(1):184-94. PMID: 18413664. Gonsette RE, Dubois B. Pixantrone (BBR2778): a new immunosuppressant in multiple sclerosis with a low cardiotoxicity. J Neurol Sci. 2004 Aug 15;223(1):81-6. Review. PMID: 15261566.