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ProductsBack/PK150 (Sorafenib Analog) [2165324-62-7]
Chemical Structure
Chemical Structure
Chemical Structure

PK150 (Sorafenib Analog) [2165324-62-7]

Research Use Only
AG-CR1-0162
AdipoGen Life Sciences
CAS Number2165324-62-7
Product group Chemicals
Estimated Purity>98%
Molecular Weight394.7
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    PK150 (Sorafenib Analog) [2165324-62-7]
  • Delivery Days Customer
    10
  • CAS Number
    2165324-62-7
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C15H8ClF5N2O3
  • Molecular Weight
    394.7
  • Scientific Description
    Analog of the anticancer drug sorafenib. PK150 is a potent antibiotic. It shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 microM, respectively. PK150 did not induce in vitro resistance and shows oral bioavailability and in vivo efficacy. The mode of action includes the interference with menaquinone biosynthesis by inhibiting demethylmenaquinone methyltransferase and the stimulation of protein secretion by altering the activity of signal peptidase IB. - Chemical. CAS: 2165324-62-7. Formula: C15H8ClF5N2O3. MW: 394.7. Analog of the anticancer drug sorafenib. PK150 is a potent antibiotic. It shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 microM, respectively. PK150 did not induce in vitro resistance and shows oral bioavailability and in vivo efficacy. The mode of action includes the interference with menaquinone biosynthesis by inhibiting demethylmenaquinone methyltransferase and the stimulation of protein secretion by altering the activity of signal peptidase IB.
  • SMILES
    O=C(NC1=CC(OC(F)(F)O2)=C2C=C1)NC3=CC=C(Cl)C(C(F)(F)F)=C3
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200