PK68

MedChem Express

PK68 [2173556-69-7]

10

2173556-69-7

Research Use Only

99.92

C22H24N4O3S

424.52

PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC 50 of ~90?nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis [1] .

O=C(OC1CCCCC1)NC2=CC(C3=CC=C4N=C(NC(C)=O)SC4=C3)=CN=C2C

-20°C,2°C to 8°C

12352200