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ProductsBack/PKC412 [120685-11-2]

PKC412 [120685-11-2]

Research Use Only
P4008
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 783,00
5 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    PKC412 [120685-11-2]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    DMSO, Dichloromethanol
  • Scientific Description
    Staurosporine derivative; PKC and FLT3 inhibitor.; Midostaurin, 4'-N-Benzoyl staurosporine
  • Storage Instruction
    4°C
  • UNSPSC
    12352200

References

  • Fischer T, Stone RM, Deangelo DJ, et al. Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. J Clin Oncol. 2010 Oct 1;28(28):4339-45. PMID: 20733134. Huang YC, Shieh HR, Chen YJ. Midostaurin (PKC412) modulates differentiation and maturation of human myeloid dendritic cells. Toxicol In Vitro. 2010 Sep;24(6):1705-10. PMID: 20685248. Stölzel F, Steudel C, Oelschlägel U, et al. Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells. Ann Hematol. 2010 Jul;89(7):653-62. PMID: 20119833. Nakazono-Kusaba A, Takahashi-Yanaga F, Miwa Y, et al. PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts. Eur J Pharmacol. 2004 Aug 23;497(2):155-60. PMID: 15306200. Yoshikawa N, Nakamura K, Yamaguchi Y, et al. Effect of PKC412, a selective inhibitor of protein kinase C, on lung metastasis in mice injected with B16 melanoma cells. Life Sci. 2003 Feb 7;72(12):1377-87. PMID: 12527035.