PKI-179

MedChem Express

PKI-179 [1197160-28-3]

10

1197160-28-3

Research Use Only

98.0

C25H28N8O3

488.54

PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC 50 s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-alpha , PI3K-beta , PI3K-gamma , PI3K-delta and mTOR , respectively. PKI-179 also exhibits activity over E545K and H1047R , with IC 50 s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo [1] [2] .

O=C(NC1=CC=NC=C1)NC2=CC=C(C3=NC(N4C5CCC4COC5)=NC(N6CCOCC6)=N3)C=C2

-20°C,2°C to 8°C

12352200