PLAT Polyclonal Antibody

Reddot Biotech

PLAT Polyclonal Antibody

5

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.4 mg/ml

Unconjugated

PLAT

plasminogen activator, tissue type

alteplase; plasminogen/activator kringle; reteplase; tissue-type plasminogen activator; TPA; T-PA; t-plasminogen activator

Rabbit

IgG

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Human

-20°C

12352203