PLEKHG6 Polyclonal Antibody

Reddot Biotech

PLEKHG6 Polyclonal Antibody

5

Western Blot, ELISA

Research Use Only

Polyclonal

0.1 mg/ml

Unconjugated

PLEKHG6

pleckstrin homology and RhoGEF domain containing G6

MyoGEF; myosin II interacting GEF; myosin interacting guanine nucleotide exchange factor; PH domain-containing family G member 6; pleckstrin homology domain containing, family G (with RhoGef domain) member 6; pleckstrin homology domain-containing family G member 6

Rabbit

IgG

PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Human, Mouse

-20°C

12352203