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ProductsBack/PLX4720 [918505-84-7]

PLX4720 [918505-84-7]

Research Use Only
P4492
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 206,00
5 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    PLX4720 [918505-84-7]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    DMSO 83 mg/mL (200.56 mM); Water Insoluble; Ethanol Insoluble
  • Scientific Description
    V600E B-Raf inhibitor.; PLX-4720
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Liu C, Peng W, Xu C, et al. BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice. Clin Cancer Res. 2013 Jan 15;19(2):393-403. PMID: 23204132. Bottos A, Martini M, Di Nicolantonio F, et al. Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):E353-9. PMID: 22203991. Wilmott JS, Long GV, Howle JR, et al. Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma. Clin Cancer Res. 2012 Mar 1;18(5):1386-94. PMID: 22156613. Boni A, Cogdill AP, Dang P, et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res. 2010 Jul 1;70(13):5213-9. PMID: 20551059.