PLX647 dihydrochloride [1779796-38-1]

TargetMol Chemicals

PLX647 dihydrochloride [1779796-38-1]

999

1779796-38-1

Chemical

Research Use Only

PLX647 dihydrochloride

C21H19Cl2F3N4

455.31

PLX647 dihydrochloride is a potent and selective dual inhibitor of FMS and KIT kinases, with IC50 values of 28 nM and 16 nM, respectively. At a concentration of 1 microM, PLX647 dihydrochloride demonstrates superior selectivity against a wide range of 400 kinases, except FLT3 and KDR, where IC50 values are 91 nM and 130 nM, respectively. This orally active compound holds great potential for targeted kinase inhibition.

3 years

Cl.Cl.FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncccc34)cn2)cc1

-20°C

12352200