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ProductsBack/Podophyllotoxin [518-28-5]
Chemical Structure
Chemical Structure
Chemical Structure

Podophyllotoxin [518-28-5]

Research Use Only
AG-CN2-0049
AdipoGen Life Sciences
CAS Number518-28-5
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight414.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Podophyllotoxin [518-28-5]
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    518-28-5
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C22H22O8
  • Molecular Weight
    414.4
  • Scientific Description
    Chemical. CAS: 518-28-5. Formula: C22H22O8. MW: 414.4. Isolated from Podophyllum emodi rhizomes. Potent microtubule assembly inhibitor. Anticancer compound. Cell death inducer. DNA topoisomerase II inhibitor. Cell cycle inhibitor at the metaphase. Antiviral and antihelminthic. - Potent microtubule assembly inhibitor [1-3]. Anticancer compound [1-5, 7]. Cell death inducer [1-5, 7]. DNA topoisomerase II inhibitor. Cell cycle inhibitor at the metaphase [2, 6, 8]. Antiviral [3, 4, 9] and antihelminthic [1].
  • SMILES
    [H][C@]12COC(=O)[C@]1([H])C(C1=CC(OC)=C(OC)C(OC)=C1)C1=C(C=C3OCOC3=C1)[C@@H]2O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UN Number
    UN 2811
  • UNSPSC
    12352200

References

  • VP16-213 and podophyllotoxin. A study on the relationship between chemical structure and biological activity: J.D. Loike; Cancer Chemother. Pharmacol. 7, 103 (1982)
  • Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents: T. Terada, et al.; Chem. Pharmacol. Bull. (Tokyo) 40, 2720 (1992)
  • Antineoplastic and antiviral activities of podophyllotoxin related lignans: M. Gordaliza, et al.; Arch. Pharmacol. 327, 175 (1994)
  • Podophyllotoxin: C. Canel, et al.; Phytochemistry 54, 115 (2000) (Review)
  • Antitumor properties of podophyllotoxin and related compounds: M. Gordaliza, et al.; Curr. Pharm. Des. 6, 1811 (2000) (Review)
  • Drugs that inhibit tubulin polymerization: the particular case of podophyllotoxin and analogues: S. Desbene & S. Giorgi-Renault; Curr. Med. Chem. Anticancer Agents 2, 71 (2002) (Review)
  • Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents: Y. You; Curr. Pharm. Des. 11, 1695 (2005) (Review)
  • Camptothecin and podophyllotoxin derivatives: inhibitors of topoisomerase I and II - mechanisms of action, pharmacokinetics and toxicity profile: J.T. Hartmann & H.P. Lipp; Drug Saf. 29, 209 (2006) (Review)
  • An evidence-based review of medical and surgical treatments of genital warts: N. Scheinfeld & D.S. Lehman; Dermatol. Online J. 12, 5 (2006)