POLE antibody
GTX132100
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetPOLE
Overview
- SupplierGeneTex
- Product NamePOLE antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:2500. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.34 mg/ml
- ConjugateUnconjugated
- Gene ID5426
- Target namePOLE
- Target descriptionDNA polymerase epsilon, catalytic subunit
- Target synonyms3'-5' exodeoxyribonuclease; CRCS12; DNA polymerase epsilon catalytic subunit A; DNA polymerase epsilon catalytic subunit protein; DNA polymerase II subunit A; FILS; IMAGEI; POLE1; polymerase (DNA directed), epsilon, catalytic subunit; polymerase (DNA) epsilon, catalytic subunit
- HostRabbit
- IsotypeIgG
- Protein IDQ07864
- Protein NameDNA polymerase epsilon catalytic subunit A
- Scientific DescriptionParticipates in DNA repair and in chromosomal DNA replication.
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Disrupted control of origin activation compromises genome integrity upon destabilization of Polepsilon and dysfunction of the TRP53-CDKN1A/P21 axis.Read more
- Novel POLE mutations identified in patients with IMAGE-I syndrome cause aberrant subcellular localisation and protein degradation in the nucleus.Read more
- Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase epsilon. Sviderskiy VO et al., 2020 Nov 19, Mol CellRead more
- POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication. Bellelli R et al., 2018 Oct 4, Mol CellRead more
- Polepsilon Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis. Bellelli R et al., 2018 May 17, Mol CellRead more
- Validating the concept of mutational signatures with isogenic cell models. Zou X et al., 2018 May 1, Nat CommunRead more