Pozanicline (dihydrochloride)

MedChem Express

Pozanicline (dihydrochloride) [161416-61-1]

10

161416-61-1

Research Use Only

99.06

C11H18Cl2N2O

265.18

Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor ( nAChR ) agonist with a K i of 16.7 nM for binding to [ 3 H]cytisine sites [1] . Pozanicline is an alpha4beta2 -selective nAChR agonist, which binds to rat brain alpha4beta2 nAChR with a K i of 17 nM while binding to alpha7 nAChR is insignificant [2] .

[H]Cl.[H]Cl.CC(N=CC=C1)=C1OC[C@@H]2CCCN2

2°C to 8°C

12352200