PP5-IN-2

MedChem Express

PP5-IN-2

9

Research Use Only

C16H15NO4

285.29

PP5-IN-2 is an orally active and selective protein phosphatase 5 (PP5) inhibitor with an IC50 value of 0.9 microM. PP5-IN-2 activates p53 and downregulates cyclin D1 and MGMT, which shows potency in cell cycle arrest and reverses Temozolomide (TMZ) (HY-17364) resistance in the U87 MG cell line. PP5-IN-2 effectively inhibits tumor growth in the xenograft mouse model[1].

O=C([C@H]1[C@](O2)([H])CC[C@]2([H])[C@H]1C(N3C=CC4=C3C=CC=C4)=O)O

12352200