PPADS

MedChem Express

PPADS [149017-66-3]

5

149017-66-3

Research Use Only

C14H14N3O12PS2

511.38

PPADS is a P2 receptor antagonist, with IC 50 s of 68 nM (P2X1) and 214 nM (P2X3). PPADS acts as an ATP (nucleotide) mimetic and competes with ATP for its binding site on P2 receptors. PPADS is also a reversible competitive antagonist of the NAADP receptor . PPADS reverses nociceptive hypersensitivity and reduces the increased NO/NOS system and IL-1beta in both peripheral and central steps of nervous system [1] [2] [3] .

O=CC1=C(C(C)=NC(/N=N/C2=CC=C(S(=O)(O)=O)C=C2S(=O)(O)=O)=C1COP(O)(O)=O)O

12352200