PPARA Polyclonal Antibody

Reddot Biotech

PPARA Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

Polyclonal

0.6 mg/ml

Unconjugated

Ppara

peroxisome proliferator activated receptor alpha

4933429D07Rik; AW742785; Nr1; Nr1c1; nuclear receptor subfamily 1 group C member 1; P; peroxisome proliferator-activated receptor alpha; PP; Ppar; PPARalpha; PPAR-alpha

Rabbit

IgG

Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid beta-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-kappaB, causing inhibition of its signaling pathway or reducing the activated levels of NF-kappaB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase.

Mouse, Rat

-20°C

12352203