Presenilin 2 antibody [198C679.2.1]

GeneTex

Presenilin 2 antibody [198C679.2.1]

9

Western Blot

Research Use Only

Monoclonal

198C679.2.1

Unconjugated

PSEN2

presenilin 2

AD3L; AD3LP; AD4; AD5; Alzheimer disease 4; CMD1V; E5-1; presenilin-2; PS2; PS-2; STM2; STM-2

Mouse

IgM

Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq]

Human

2°C to 8°C,-20°C or -80°C

12352203