PRKRA Antibody, Biotin conjugated

Cusabio

PRKRA Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

PRKRA

protein activator of interferon induced protein kinase EIF2AK2

DYT16; HSD14; interferon-inducible double-stranded RNA-dependent protein kinase activator A; PACT; PKR-associated protein X; PKR-associating protein X; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double-stranded RNA-dependent activator; RAX

Rabbit

IgG

Interferon-inducible double-stranded RNA-dependent protein kinase activator A

Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at \Lys-386\ at \Ser-392\ respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

Human

-20°C or -80°C

12352203