PRMT5-IN-1 hydrochloride

MedChem Express

PRMT5-IN-1 hydrochloride

10

Research Use Only

99.5%

C19H20Cl2N4O5

455.29

PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions.

O[C@@H]1[C@@H]([C@@H](C2=CC=C(Cl)C=C2)O)O[C@@H](N3C=CC4=C3N=CN5C4=NCC5O)[C@@H]1O.[H]Cl

2°C to 8°C,-20°C,-80°C

12352200