PRMT5-IN-19
HY-149005
Molecular Weight396.48
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NamePRMT5-IN-19
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC25H24N4O
- Molecular Weight396.48
- Scientific DescriptionPRMT5-IN-19 (Compound 41) is an selective orally active non-nucleoside PRMT5 inhibitor with IC50 values of 23.9 nM (radioactive biochemical assay) and 47 nM (AlphaLISA assay). PRMT5-IN-19 can occupy the SAM-binding pocket in PRMT5 and block methyltransferase activity, which displays good selectivity over other PRMTs and PKMTs. PRMT5-IN-19 inhibits cell proliferation by inducing cell apoptosis, and can be used for cancer-related research.
- SMILESC[C@H](OC1=CC=C(C2=CC3=C(N=CN=C3N2)C4=CCNCC4)C=C1)C5=CC=CC=C5
- Storage InstructionSee Manual
- UNSPSC12352200