Progranulin (human) ELISA Kit

AdipoGen Life Sciences

Progranulin (human) ELISA Kit

10

ELISA

0.063 to 4ng/ml

32pg/ml

Detects human progranulin.

Research Use Only

ELISA Assay. Detects human progranulin. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum, Urine. Range: 0.063 to 4ng/ml. Sensitivity: 32pg/ml. Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. New cutting-edge publications have shown that progranulin might be a biomarker not only for FTLD, but also for other types of Alzheimers disease (AD). This new data even supposes the potential of progranulin to be a biomarker for MCI (Mild Cognitive Impairment), which would be a hallmark in AD research. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. - Progranulin (PGRN) is a widely expressed pluripotent growth factor that plays a role in processes such as development, wound repair, and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. New cutting-edge publications have shown that progranulin might be a biomarker not only for FTLD but also for other types of Alzheimers disease (AD). This new data even suppose the potential of progranulin to be a biomarker for MCI (Mild Cognitive Impairment), which would be a hallmark in AD research. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory diseases like arthritis. Progranulin expression in plasma predicts GRN mutations status, independently of symptom onset proximity. Progranulin loss-of-function mutations are among the most frequent genetic causes, responsible for 20% of familial FTLD. If a patient carries a mutation in the progranulin gene, it can be detected using AdipoGens Progranulin (human) ELISA Kit. This is the only and unique kit on the market detecting all mutations of Progranulin [Reference 58].

2°C to 8°C

41116158