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Progranulin (mouse) ELISA Kit

Research Use Only
AG-45A-0019YTP
AdipoGen Life Sciences
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Progranulin (mouse) ELISA Kit
  • Delivery Days Customer
    10
  • Applications
    ELISA
  • Assay Detection Range
    0.125 to 8ng/ml
  • Assay Sensitivity
    60pg/ml
  • Assay Specificity
    Detects mouse progranulin. Does not cross-react with human progranulin.
  • Certification
    Research Use Only
  • Scientific Description
    ELISA Assay. Detects mouse progranulin. Does not cross-react with human progranulin. Colorimetric assay. Sample Types: Cell Culture Supernatant, Serum. Range: 0.125 to 8ng/ml. Sensitivity: 60pg/ml. Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. New cutting-edge publications have shown that progranulin might be a biomarker not only for FTLD, but also for other types of Alzheimers disease (AD). This new data even supposes the potential of progranulin to be a biomarker for MCI (Mild Cognitive Impairment), which would be a hallmark in AD research. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. - Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. New cutting-edge publications have shown that progranulin might be a biomarker not only for FTLD, but also for other types of Alzheimers disease (AD). This new data even supposes the potential of progranulin to be a biomarker for MCI (Mild Cognitive Impairment), which would be a hallmark in AD research. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116158

References

  • Microglial upregulation of progranulin as a marker of motor neuron degeneration: T. Philips, et al.; J. Neuropathol. Exp. Neurol. 69, 1191 (2010)
  • Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3beta phosphorylation: T. Nedachi, et al.; Neuroscience 185, 106 (2011)
  • The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function: O.A. Brady, et al.; Hum. Mol. Genet. 22, 685 (2013)
  • Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice: A.J. Filiano, et al.; J. Neurosci. 33, 5352 (2013)
  • Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor B (RANK)-dependent formation of multinucleated osteoclasts: J. Oh, et al.; J. Biol. Chem. 290, 2042 (2015)