PROTAC 20S proteasome subunit beta5 degrader 2

MedChem Express

PROTAC 20S proteasome subunit beta5 degrader 2

9

Research Use Only

C46H52BN5O10

845.74

PROTAC 20S proteasome subunit beta5 degrader 2 is a PROTAC degrader for 20S proteasome subunit beta5, with a DC50 of 0.16 microM. PROTAC 20S proteasome subunit beta5 degrader 2 inhibits the proliferation of cancer cell FaDu with IC50 of 0.23 microM. PROTAC 20S proteasome subunit beta5 degrader 2 exhibits antitumor efficacy in mice models[1].

O=C1CCC(C(N1)=O)N2C(C3=C(C(OCC(NC4=CC=C(C=C4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](B6O[C@@]7(C)[C@@H](C[C@H]8CC7O6)C8(C)C)CC(C)C)=O)=O)=O)=CC=C3)C2=O)=O

12352200