PROTAC ALK degrader-3

MedChem Express

PROTAC ALK degrader-3

9

Research Use Only

C50H60ClN9O7S

966.59

PROTAC ALK degrader-3 (4B) is an orally active ALK degrader based on PROTACs, which can effectively induce persistent degradation of ALK fusion protein in Karpas 299 cells and strong inhibition of downstream pathways,IC50 is 119.33 nM. PROTAC ALK degrader-3 exhibits antitumor activity. (Srtucture Note: PINK, ALK Inhibitor (HY-15656); Blue, E3 (HY-W023573); Black, linker (HY-168552))[1].

CC1=C(C=C(C(NC2=NC=C(C(NC3=CC=CC=C3S(=O)(C(C)C)=O)=N2)Cl)=C1)OC(C)C)C4CCN(CC4)C5CN(C5)C6CCC(CC6)NC7=CC=C8C(N(C(C8=C7)=O)C9CCC(NC9=O)=O)=O

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