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PROTAC alpha-Synuclein/Tau degrader 1

HY-157839
MedChem Express
Estimated Purity99.28
Product group Chemicals
Molecular Weight729.80
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PROTAC alpha-Synuclein/Tau degrader 1
  • Delivery Days Customer
    5
  • Certification
    Research Use Only
  • Estimated Purity
    99.28
  • Molecular Formula
    C37H39N5O9S
  • Molecular Weight
    729.80
  • Scientific Description
    PROTAC alpha-Synuclein/Tau degrader 1 is a blood-brain barrier-penetrant dual PROTAC degrader of alpha-synuclein (alpha-Syn) and tau, with DC50 of 1.57 microM and 4.09 microM, respectively. PROTAC alpha-Synuclein/Tau degrader 1 binds to alpha-Syn and tau PFF, with KDs of 0.47 and 2.78 microM, respectively. PROTAC alpha-Synuclein/Tau degrader 1 exhibits degradation effect mediated by the ubiquitin-proteasome system (UPS). PROTAC alpha-Synuclein/Tau degrader 6 can be used for the study of Parkinsons disease (PD) (Pink: alpha-Synuclein/Tau ligand (HY-151035); Blue: CRBN ligase ligand (HY-14658); Black: Linker (HY-128803))[1].
  • SMILES
    O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCOCCNC4=CC=C(C(S5)=NC6=C5C=C(C)C=C6)C=C4)=O)=C3C1=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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