PROTAC AR-NTD degrader 1

TargetMol Chemicals

PROTAC AR-NTD degrader 1

999

Chemical

Research Use Only

PROTAC AR-NTD degrader 1

C41H47ClN6O7

771.3

PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule from the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal domain (AR-NTD) of the Androgen Receptor variant AR-V7. By antagonizing AR-NTD, it effectively degrades AR-V7 protein and induces apoptosis in prostate cancer (PC) cells, with degradation efficiencies of 62.2% (1 microM) and 71.1% (5 microM) in VCaP cells [1].

3 years

-20°C

51202000