PROTAC BRD4 Degrader-13 [2417370-71-7]
HY-138636
Product group Molecular Biology
Overview
- SupplierMedChem Express
- Product NamePROTAC BRD4 Degrader-13 [2417370-71-7]
- Delivery Days Customer5
- CAS Number2417370-71-7
- CertificationResearch Use Only
- Molecular FormulaC68H85F2N11O17P2S2
- Molecular Weight1492.54
- Scientific DescriptionPROTAC BRD4 Degrader-13 (compound 9d) is a von Hippel-Lindau system-based PROTAC BRD4 degrader with a linker that can be coupled to ADC antibodies to form PACs (PROTAC-antibody Conjugates). PROTAC BRD4 Degrader-13 can be coupled to STEAP1 and CLL1 antibodies to degrade BRD4 protein in PC3 prostate cancer cells with DC50 values of 0.025 nM and 6.0 nM, respectively[1].
- SMILESCC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@H](CN3C([C@@H](NC(CCCCCCCCCCNC(C4=CC(N(C5=NC=C(F)C=C5F)CC6=CNC7=C6C8=CN(C)C7=O)=C8C=C4CS(=O)(C)=O)=O)=O)C(C)(C)C)=O)OP(OP(OCCNC(CCCCCN9C(C=CC9=O)=O)=O)(O)=O)(O)=O)=O)C=C2
- UNSPSC41116133