Bio-Connect

PROTAC BRD4 Degrader-13 [2417370-71-7]

Research Use Only
HY-138636
MedChem Express
Product group Molecular Biology
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PROTAC BRD4 Degrader-13 [2417370-71-7]
  • Delivery Days Customer
    5
  • CAS Number
    2417370-71-7
  • Certification
    Research Use Only
  • Molecular Formula
    C68H85F2N11O17P2S2
  • Molecular Weight
    1492.54
  • Scientific Description
    PROTAC BRD4 Degrader-13 (compound 9d) is a von Hippel-Lindau system-based PROTAC BRD4 degrader with a linker that can be coupled to ADC antibodies to form PACs (PROTAC-antibody Conjugates). PROTAC BRD4 Degrader-13 can be coupled to STEAP1 and CLL1 antibodies to degrade BRD4 protein in PC3 prostate cancer cells with DC50 values of 0.025 nM and 6.0 nM, respectively[1].
  • SMILES
    CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@H](CN3C([C@@H](NC(CCCCCCCCCCNC(C4=CC(N(C5=NC=C(F)C=C5F)CC6=CNC7=C6C8=CN(C)C7=O)=C8C=C4CS(=O)(C)=O)=O)=O)C(C)(C)C)=O)OP(OP(OCCNC(CCCCCN9C(C=CC9=O)=O)=O)(O)=O)(O)=O)=O)C=C2
  • UNSPSC
    41116133