PROTAC ER Degrader-4

MedChem Express

PROTAC ER Degrader-4 [2361114-15-8]

10

2361114-15-8

Research Use Only

98.78

C53H67F3N6O8S

1005.19

PROTAC ER Degrader-4 is a von Hippel-Lindau -based PROATC estrogen receptor ( ER ) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC 50 of 0.3 nM [1] .

CC(C)(F)CN1[C@H](C2=C(C=C(OCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@@H](O)C3)C(N[C@H](C4=CC=C(C5=C(N=CS5)C)C=C4)C)=O)=O)=O)C=C2F)F)C6=C(C7=CC=CC=C7N6)C[C@H]1C

-20°C

12352200