PROTAC EZH2 Degrader-1

MedChem Express

PROTAC EZH2 Degrader-1

10

Research Use Only

99.44

C54H67N7O8

942.15

PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC 50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes [1] .

CCN(C1CCOCC1)C2=C(C(C(NCC3=C(C=C(NC3=O)C)C)=O)=CC(C4=CC=C(C=C4)CN5CCN(CC5)CCCCCCCOC6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=C2)C

-20°C

12352200