PROTAC EZH2 Degrader-3

MedChem Express

PROTAC EZH2 Degrader-3

9

Research Use Only

C56H68N8O8

981.19

PROTAC EZH2 Degrader-3 (compound ZJ-20) is a EZH2 degrader. PROTAC EZH2 Degrader-3 (5 microM, 24 h) not only potently inhibits the expression of EZH2 protein, but also had a strong inhibits effect on the expression levels of other subunits of PRC2 as well as H3k27me3 protein. PROTAC EZH2 Degrader-3 shows anti-proliferative activity and blocks the cell cycle in the G0-G1 phase and induces cell apoptosis((Blue: cereblon ligand Pomalidomide (HY-10984), Black: linker HY-W361751; Pink: EZH2 inhibitor Tazemetostat (HY-13803))[1].

CCN(C1CCOCC1)C2=CC(C3=CC=C(CN4CCN(C(CC5CCC(CNC6=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=CC=C6)CC5)=O)CC4)C=C3)=CC(C(NCC9=C(C)C=C(C)NC9=O)=O)=C2C

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