PROTAC GSPT1 degrader-2 [3024909-61-0]

TargetMol Chemicals

PROTAC GSPT1 degrader-2 [3024909-61-0]

9

Research Use Only

C38H38ClN7O5

708.21

PROTACGSPT1 degrader-2 (compound A) acts as a molecular glue for GSPT1, achieving degradation efficiencies exceeding 95%. Meanwhile, GSPT1 degrader-8 exhibits inhibitory effects on HL-60 cells, demonstrating an IC50 of 10 nM.

O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)N4CCC(CN5C(=O)N(C=6C=CC=C(C6)C=7C=NC=8NC=C(C8C7Cl)CC)CCC5)CC4)CC1

-20°C

51202000