PROTAC HPK1 Degrader-1

MedChem Express

PROTAC HPK1 Degrader-1

5

Research Use Only

C43H43N7O8

785.84

PROTAC HPK1 Degrader-1 (Compound B1) is a potent HPK1 degrader with DC50 value of 1.8 nM. PROTAC HPK1 Degrader-1 inhibits phosphorylation of the SLP76 protein with IC50 value of 496.1 nM. PROTAC HPK1 Degrader-1 is a bona fide HPK1-PROTAC degrader, which provided a potential tool for further HPK1 investigation in TCR signaling[1].

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCC(N4CCN(C5=CC=C(C6=CN=C(NC=C7C8=CC=C(OC)C(OC)=C8)C7=C6)C=C5)CC4)=O)=O

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