PROTAC HSP90 degrader BP3 [2669072-88-0]

TargetMol Chemicals

PROTAC HSP90 degrader BP3 [2669072-88-0]

999

Chemical

Research Use Only

PROTAC HSP90 degrader BP3

C32H29ClN8O5

641.08

PROTAC HSP90 degrader BP3 potently and selectively degrades HSP90 through a CRBN-dependent mechanism. It effectively diminishes HSP90 protein levels in MCF-7 cells with a half-maximal degradation concentration (DC50) of 0.99 microM. Additionally, this compound impedes the proliferation of breast cancer cells [1].

3 years

COc1c(C)cnc(Cn2cc(C#CCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)c3c(Cl)nc(N)nc23)c1C

-20°C

51202000