PROTAC PARP1 degrader-2 [2923686-62-6]

TargetMol Chemicals

PROTAC PARP1 degrader-2 [2923686-62-6]

9

Research Use Only

C38H37F2N9O6

753.75

PROTACPARP1 degrader-2 (Compound 72) is a potent PROTAC degrader of PARP, achieving a DC50 of less than 10 nM in MDA-MB-231 cells. Additionally, this compound effectively inhibits the viability of MDA-MB-436 cells with an IC50 of less than 100 nM. (Blue: ligand for target protein; Pink: ligand for E3 ligase).

O=C(NC1CCN(C2=CC=C3C(=O)N(C(=O)C3=C2)C4C(=O)NC(=O)CC4)CC1)C5=NC(F)=C(C=C5)N6CCN(CC=7C=CC=8N=C(C(=O)NC8C7F)C)CC6

-20°C

51202000