PROTAC TYK2 degrader-1 [2770470-20-5]

TargetMol Chemicals

PROTAC TYK2 degrader-1 [2770470-20-5]

16

Research Use Only

C40H41N13O7

815.84

PROTAC TYK2 degrader-1 (CPD-155) functions as a selective degrader of TYK2, demonstrating a degradation maximum (D max) greater than 60%. (Structure Note: PINK, TYK2 ligand 1; Blue, VHL ligand Thalidomide; Black, linker). This compound effectively targets TYK2 for degradation, utilizing a linker to connect the TYK2 ligand with the VHL ligand Thalidomide, each color-coded for identification.

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCCCNC(=O)C=4C=CC(NC5=CC(NC6=C(OC)C(=CC=C6)C=7N=CN(C)N7)=C(C(NC)=O)N=N5)=NC4

-20°C

51202000