Belgium

Luxembourg

Netherlands

Proteases

Restriction / modifying enzymes

Chimerigen Laboratories

Supplier

Research Use Only

Certification

Bio-Connect Life Sciences

Business unit

CHI-B232008 | ACE2 (human) (rec.) (His) | Chimerigen Laboratories available at Bio-Connect | Order online now!

ACE2 (human) (rec.) (His) | CHI-B232008 | Chimerigen Laboratories

ACE2 (human) (rec.) (His)

Molecular Biology

Angiotensin-converting enzyme 2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19. It has been shown that human recombinant soluble ACE2 can significantly block early stages of SARS-CoV-2 infections. - Recombinant Proteins. Extracellular domain of human ACE2 (aa 1-740) is fused at the C-terminus to a His-tag. Source: HEK 293 cells. Lyophilized. Contains PBS. Endotoxin levels: <0.001EU/microg purified protein (LAL test).. Angiotensin-converting enzyme 2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19. It has been shown that human recombinant soluble ACE2 can significantly block early stages of SARS-CoV-2 infections.

Tech support

News

Our company

Our people

Divisions

Vacatures

Events

Promotions

About us

Contact

Antibodies

Chemicals

Proteins / Signaling Molecules

Assays

(Cell) Culture

Products

Suppliers

Industries

Bio-Connect

Cancer

Epigenetics

Immunology and inflammation

Neuroscience

Virology

SARS-CoV-2

Research

Disclaimer

Privacy Statement

Terms and conditions

Are you looking for specific products, alternatives, documentation or need assistance with solving product related issues? Let our in-house technical support team help you.

We support your research

<p>For 15 years, we connect life science researchers specialized in the import and distribution of life science reagents from global suppliers.</p>

Support your research

DNA / RNA / Vectors

Cell Culture

Genome Editing and Engineering

Lysates / Extracts

Expression

Labware / Accesories

Body Products

Technique Specific Products

Arrays / Slides

Cancer research

Epigenetics research

Immunology and inflammation research

Neuroscience research

Virology research

Call +31 (0)26 326 44 50

Proteases

Didn't find what you were looking for?