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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
CD152 [CTLA-4] (human):Fc (human) (rec.)
Catalog number:
CHI-HF-210A4-C100
Brand:
Chimerigen Laboratories
Packing:
100 ug
Other sizes:
Other sizes available
Price:
€ 95.00
Expected delivery time:
7 days
Quantity:
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General
References
Product specifications for - CD152 [CTLA-4] (human):Fc (human) (rec.)
Overview:
Product group:
Proteins / Signaling Molecule
Category:
Proteins
Species:
Human
Properties:
Purity:
>98% (SDS-PAGE)
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352202
Form supplied:
Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
CD152 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28. - Protein. The extracellular domain of human CD152 [CTLA-4] (aa 37-160) is fused to the N-terminus of the Fc region of human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/microg protein (LAL test; Lonza). Lyophilized from 0.2microm-filtered solution in PBS. Purity: >98% (SDS-PAGE). CD152 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
Safety information:
Hazard information:
Non-hazardous
Additional information:
Synonyms:
CHI-HF-210A4-C100; Chimerigen Laboratories
Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg: D.J. Lenschow, et al.; Science 257, 789 (1992)
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Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement: V.L. Perez, et al.; Immunity 6, 411 (1997)
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Ligation of B7-1/B7-2 by Human CD4 T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells: D.H. Munn, et al.; J. Immunol. 172, 4100 (2004)
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CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-kappaB subunits on IL-8 and Bcl-xL gene promoters: B. Marinari, et al.; PNAS 101, 6098 (2004)
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An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies: D. Schönfeld, et al.; PNAS 106, 8198 (2009)
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