IL-10 (human):Fc (human)... | CHI-HF-22010-C050

Product specifications for - IL-10 (human):Fc (human) (rec.) (non-lytic)

Overview:
Product group:	Proteins / Signaling Molecule
Category:	Chemokines / cytokines
Species:	Human

Properties:
Purity:	>98% (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352202
Form supplied:	Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions:	2-¦C to 8-¦C, -20-¦C

Scientific information:
Scientific info:	Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases. - Protein. The extracellular domain of human IL-10 (aa 19-178) is fused to the N-terminus of the Fc region of a mutant human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/microg protein (LAL test; Lonza). Lyophilized from 0.2microm-filtered solution in PBS. Purity: >98% (SDS-PAGE). Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

Scientific information:

Scientific info:

Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases. - Protein. The extracellular domain of human IL-10 (aa 19-178) is fused to the N-terminus of the Fc region of a mutant human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/microg protein (LAL test; Lonza). Lyophilized from 0.2microm-filtered solution in PBS. Purity: >98% (SDS-PAGE). Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

Safety information:
Hazard information:	Non-hazardous

Additional information:
Synonyms:	CHI-HF-22010-C050; Chimerigen Laboratories

Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation: X.X. Zheng, et al.; J. Immunol. 154, 5590 (1995)

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IL-10 (human):Fc (human) (rec.) (non-lytic)

Product specifications for - IL-10 (human):Fc (human) (rec.) (non-lytic)

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IL-10 (human):Fc (human) (rec.) (non-lytic)

Product specifications for - IL-10 (human):Fc (human) (rec.) (non-lytic)