Binding of LAG-3 (human):Fc (human) (rec.) (Prod. No. AG-40B-0031) on dendritic and B cells. Method: Monocyte-derived immature DC (iDC), DC matured for 48h with LPS (mDC) and EBV-transformed B-cells are incubated with either an anti-
Binding of LAG-3 (human):Fc (human) (rec.) (Prod. No. AG-40B-0031) on dendritic and B cells. Method: Monocyte-derived immature DC (iDC), DC matured for 48h with LPS (mDC) and EBV-transformed B-cells are incubated with either an anti-
LAG-3 (human):Fc (human) (rec.)
AG-40B-0031
Overview
- SupplierAdipoGen Life Sciences
- Product NameLAG-3 (human):Fc (human) (rec.)
- Delivery Days Customer10
- CertificationResearch Use Only
- Concentration0.5 mg/ml
- Estimated Purity>99%
- FormulationLiquid
- Protein IDP18627
- Protein NameLymphocyte activation gene 3 protein
- Scientific DescriptionLymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4. - Protein. The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1. Source: CHO cells. Endotoxin content: <0.1EU/microg purified protein (LAL test; Lonza). Liquid. In PBS. Binds to human, mouse and monkey MHC class II. Purity: >99% (SDS-PAGE). Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352202