PF-4708671 [1255517-76-0]

Catalog number: HY-15773_10mg
Brand: MedChem Express
Packing: 10 mg
Other sizes: 10 mM
50 mg
100 mg
Price: € 113.00
Expected delivery time: 10 days

Product specifications for - PF-4708671 [1255517-76-0]

Product group: Proteins / Signaling Molecule
Category: Other
CAS No.: 1255517-76-0
Purity: >98%
Molecular Formula: C19H21F3N6
Molecular weight: 390.41
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), with a Ki of 20 nM and IC50 of 160 nM. IC50 Value: 160 nM [1] Target: S6K1 PF-4708671 is a novel cell-permeable inhibitor of S6K1, which specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 was also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR [1].
Safety information: 
mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances', Chen Xianwei. J Proteomics. 2016 Feb 2;136:13-24. Read more