Progranulin (human) (rec.) (untagged)

Catalog number: AG-40A-0188Y-C010
Brand: AdipoGen Life Sciences
Packing: 10 ug
Other sizes: Other size available
Price: € 195.00
Expected delivery time: 7 days
Quantity:

Product specifications for - Progranulin (human) (rec.) (untagged)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Species: Human
Target: GRN
Target description: granulin precursor
Properties: 
Purity: >98% (SDS-PAGE)
Molecular weight: ~74kDa (glycosylated protein by SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized. Contains PBS.
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimers Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. - Protein. Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa. Source: HEK 293 cells. Endotoxin content: <0.01EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Purity: >98% (SDS-PAGE). Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimers Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Gene ID: 2896
Swiss prot ID: P28799
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Additional information: 
Synonyms: AG-40A-0188Y-C010; AdipoGen Life Sciences; acrogranin; CLN11; GEP; GP88; granulin-epithelin; granulins; PC cell-derived growth factor; PCDGF; PEPI; PGRN; proepithelin; progranulin
Involvement of Progranulin in Hypothalamic Glucose Sensing and Feeding Regulation: H.K. Kim, et al.; Endocrinology 152, 4672 (2011) Read more
Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains: J. Jian, et al.; FEBS Lett. 587, 3428 (2013) Read more
Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor B (RANK)-dependent formation of multinucleated osteoclasts: J. Oh, et al.; J. Biol. Chem. 290, 2042 (2015) Read more
New discovery rarely runs smooth: an update on progranulin/TNFR interactions: B.C. Wang, et al.; Protein Cell 6, 792 (2015) Read more