Progranulin (rat) (rec.)

Catalog number: AG-40A-0194-C010
Brand: AdipoGen Life Sciences
Packing: 10 ug
Other sizes: Other size available
Price: € 180.00
Expected delivery time: 7 days
Quantity:

Product specifications for - Progranulin (rat) (rec.)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Species: Rat
Properties: 
Purity: >95% (SDS-PAGE)
Molecular weight: ~65kDa (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from 0.2um-filtered solution in PBS.
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimers Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. - Protein. Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: <0.1EU/microg purified protein (LAL test; Lonza). Lyophilized from 0.2microm-filtered solution in PBS. Purity: >95% (SDS-PAGE). Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimers Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Additional information: 
Synonyms: AG-40A-0194-C010; AdipoGen Life Sciences