RSPO1/R-spondin-1, Human (CHO, His)

MedChem Express

RSPO1/R-spondin-1, Human (CHO, His)

10

Research Use Only

98.0

RSPO1/R-spondin-1 is a potent activator of the Wnt/beta-catenin signaling pathway and a secretory glycoprotein belonging to the R-spondin family. RSPO1 homotetramers synergize with LRP5/6 via LGR4/5/6 and activate the Wnt/beta-catenin pathway by inhibiting DKK1/Kremen-mediated LRP6 endocytosis. RSPO1 promotes beta-catenin nuclear translocation, drives HSC activation in liver fibrosis, inhibits adipocyte thermogenic gene expression, and promotes intestinal epithelial proliferation[1][2][3][4]. RSPO1/R-spondin-1 Protein, Human (CHO, His) is a recombinant human RSPO1 protein expressed in CHO cells with a C-6*His tag.

-20°C

12352202