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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
TNF-alpha (mouse) (multimeric) (rec.)
Catalog number:
AG-40B-0021-C010
Brand:
AdipoGen Life Sciences
Packing:
10 ug
Other sizes:
Other size available
Price:
€ 195.00
Expected delivery time:
7 days
Quantity:
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General
Product specifications for - TNF-alpha (mouse) (multimeric) (rec.)
Overview:
Product group:
Proteins / Signaling Molecule
Category:
Proteins
Target:
Tnf
Target description:
tumor necrosis factor
Properties:
Purity:
>95% (SDS-PAGE)
Molecular weight:
~34kDa (SDS-PAGE)
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352202
Concentration:
0.1 mg/ml
Form supplied:
Lyophilized. Contains PBS.
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Protein. The extracellular domain of mouse TNF-alpha (aa 77-235) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: <0.02EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse TNF-R1 and TNF-R2. Purity: >95% (SDS-PAGE). Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MultimericTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (TNF-alpha (mouse) (multimeric) (rec.) (Prod. No. AG-40B-0021). Since the MultimericTNF-alpha™ mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either normal TNF-alpha or MultimericTNF-alpha™ can be used. - Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MultimericTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (TNF-alpha (mouse) (multimeric) (rec.) (Prod. No. AG-40B-0021). Since the MultimericTNF-alpha™ mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either normal TNF-alpha or MultimericTNF-alpha™ can be used.
Gene ID:
21926
Swiss prot ID:
P06804
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous
Additional information:
Synonyms:
AG-40B-0021-C010; AdipoGen Life Sciences; cachectin; DIF; Tnfa; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; Tnlg1f; tumor necrosis factor; tumor necrosis factor ligand 1f; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha