VISTA (human):COMP (mouse) (rec.) (His)

Catalog number: AG-40B-0183-C050
Brand: AdipoGen Life Sciences
Packing: 50 ug
Price: € 415.00
Expected delivery time: 7 days
Quantity:

Product specifications for - VISTA (human):COMP (mouse) (rec.) (His)

Overview: 
Product group: Proteins / Signaling Molecule
Category: Proteins
Species: Human
Target: VSIR
Target description: V-set immunoregulatory receptor
Properties: 
Purity: >95% (SDS-PAGE)
Molecular weight: ~40-55kDa (SDS-PAGE) and >500kDa (Size Exclusion Chromatography (SEC))
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352202
Concentration: 1 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. Recently, it has been reported that the recombinant VISTA protein needs to be multimerized to be active as soluble ligand. The protein VISTA (human):COMP (mouse) (with the extracellular domain of VISTA (human) fused to the pentamerization domain from the cartilage oligomeric matrix protein (COMP)), but not VISTA-Fc, functions as an immunosuppressive agonist in vivo inhibiting the proliferation of CD4+ T cells. - Recombinant protein. The extracellular domain of human VISTA (aa 33-194) is fused at the C-terminus to the domain of the mouse cartilage oligomeric matrix protein (COMP) (aa 28-72) and a His Tag. Source/Host: HEK 293 cells. Purity: >95% (SDS-PAGE). Lyophilized. Contains PBS. Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. Recently, it has been reported that the recombinant VISTA protein needs to be multimerized to be active as soluble ligand. The protein VISTA (human):COMP (mouse) (with the extracellular domain of VISTA (human) fused to the pentamerization domain from the cartilage oligomeric matrix protein (COMP)), but not VISTA-Fc, functions as an immunosuppressive agonist in vivo inhibiting the proliferation of CD4+ T cells.
Gene ID: 64115
Swiss prot ID: Q9H7M9
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Additional information: 
Synonyms: AG-40B-0183-C050; AdipoGen Life Sciences; B7H5; B7-H5; C10orf54; DD1alpha; Death Domain1alpha; GI24; PD-1H; PDCD1 homolog; platelet receptor GI24; PP2135; sisp-1; SISP1; stress-induced secreted protein-1; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; V-type immunoglobulin domain-containing suppressor of T-cell activation
Prodeus A, Abdul-wahid A, Sparkes A, et al. VISTA.COMP - an engineered checkpoint receptor agonist that potently suppresses T cell-mediated immune responses. JCI Insight. 2017;2(18) Read more