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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
VISTA (human):COMP (mouse) (rec.) (His)
Catalog number:
AG-40B-0183-C050
Brand:
AdipoGen Life Sciences
Packing:
50 ug
Price:
€ 415.00
Expected delivery time:
7 days
Quantity:
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General
References
Product specifications for - VISTA (human):COMP (mouse) (rec.) (His)
Overview:
Product group:
Proteins / Signaling Molecule
Category:
Proteins
Species:
Human
Target:
VSIR
Target description:
V-set immunoregulatory receptor
Properties:
Purity:
>95% (SDS-PAGE)
Molecular weight:
~40-55kDa (SDS-PAGE) and >500kDa (Size Exclusion Chromatography (SEC))
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352202
Concentration:
1 mg/ml
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. Recently, it has been reported that the recombinant VISTA protein needs to be multimerized to be active as soluble ligand. The protein VISTA (human):COMP (mouse) (with the extracellular domain of VISTA (human) fused to the pentamerization domain from the cartilage oligomeric matrix protein (COMP)), but not VISTA-Fc, functions as an immunosuppressive agonist in vivo inhibiting the proliferation of CD4+ T cells. - Recombinant protein. The extracellular domain of human VISTA (aa 33-194) is fused at the C-terminus to the domain of the mouse cartilage oligomeric matrix protein (COMP) (aa 28-72) and a His Tag. Source/Host: HEK 293 cells. Purity: >95% (SDS-PAGE). Lyophilized. Contains PBS. Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. Recently, it has been reported that the recombinant VISTA protein needs to be multimerized to be active as soluble ligand. The protein VISTA (human):COMP (mouse) (with the extracellular domain of VISTA (human) fused to the pentamerization domain from the cartilage oligomeric matrix protein (COMP)), but not VISTA-Fc, functions as an immunosuppressive agonist in vivo inhibiting the proliferation of CD4+ T cells.
Gene ID:
64115
Swiss prot ID:
Q9H7M9
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous
Additional information:
Synonyms:
AG-40B-0183-C050; AdipoGen Life Sciences; B7H5; B7-H5; C10orf54; DD1alpha; Death Domain1alpha; GI24; PD-1H; PDCD1 homolog; platelet receptor GI24; PP2135; sisp-1; SISP1; stress-induced secreted protein-1; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; V-type immunoglobulin domain-containing suppressor of T-cell activation
Prodeus A, Abdul-wahid A, Sparkes A, et al. VISTA.COMP - an engineered checkpoint receptor agonist that potently suppresses T cell-mediated immune responses. JCI Insight. 2017;2(18)
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