PSB-17365

TargetMol Chemicals

PSB-17365

65

2189700-03-4

Chemical

PSB-17365

C12H12BrN3O2

310.15

PSB-17365 is a potent GPR84 agonist. PSB-17365 exhibits EC50 values vs. GPR84 of 2.5nM in a cAMP accumulation assay, and 100nM in a bèta-arrestin 2 recruitment assay. No direct binding affinities are provided. PSB-17365 is selective for GPR84 compared to other free fatty acid receptors (FFAR1 and FFAR4). GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer.

3 years

N(CCC1=CC=C(Br)C=C1)C2=CC(=O)NC(=O)N2

-20°

12352200