PSEN1 Antibody, Biotin conjugated
CSB-PA018846ED01HU
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetPSEN1
Overview
- SupplierCusabio
- Product NamePSEN1 Antibody, Biotin conjugated
- Delivery Days Customer20
- ApplicationsELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateBiotin
- Gene ID5663
- Target namePSEN1
- Target descriptionpresenilin 1
- Target synonymsACNINV3; AD3; FAD; presenilin-1; PS1; PS-1; S182
- HostRabbit
- IsotypeIgG
- Protein IDP49768
- Protein NamePresenilin-1
- Scientific DescriptionProbable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203