PSEN1 Antibody

Cusabio

PSEN1 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis. Yanzhu Liu, J. Lipid Res., Dec 2004; 45: 2368 - 2376. I. Imafuku, J. Cell Biol., Oct 1999; 147: 121. Angeliki Louvi, Development, Jul 2004; 131: 3093 - 3105. Wim G. Annaert, J. Cell Biol., Oct 1999; 147: 277.

Human

-20°C or -80°C

12352203