PSENEN Polyclonal Antibody

Reddot Biotech

PSENEN Polyclonal Antibody

5

Western Blot

Research Use Only

1 mg/ml

Unconjugated

PSENEN

presenilin enhancer, gamma-secretase subunit

ACNINV2; gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; MDS033; MSTP064; PEN2; PEN-2; presenilin enhancer 2 homolog

Rabbit

IgG

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimers disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.

Human, Mouse, Rat

-20°C

12352203